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- WOMEN HEALTH: - REPRODUCCTION: -Epigenetics and assisted reproduction
Purpose of review: Epigenetics encompasses multiple mechanisms by which DNA transcription is altered in various tissues and at different times without changing the underlying gene sequence. ...
- FULLTEXT: -AUTOIMMUNITY: -Scleroderma
Scleroderma (systemic sclerosis) is a complex disease in which extensive fibrosis, vascular alterations, and autoantibodies against various cellular antigens are among the principal features (Figure ...
- AUTOINMUNIDAD: -Differences in anti-phosphatidylserine–prothrombin complex antibodies and cutaneous vasculitis between regular livedo reticularis and livedo racemosa
Objectives. We examined the prevalence of LAC, aCL antibodies (Abs), anti-β2-glycoprotein I (anti-β2GPI) Abs and anti-phosphatidylserine–prothrombin complex (anti-PS/PT) Abs in patients ...
- AUTOIMMUNITY: -The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF
The MerTK receptor tyrosine kinase is an important negative regulator of dendritic cell function and is required to prevent B cell autoimmunity in vivo. It is not currently known however, if any ...
- LIPIDS: IMMUNO-STIMULATION BY SIMVASTATIN: -Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers
Statins exert a number of anti-inflammatory and immunomodulatory effects in vitro. However, the immunomodulatory effects in vivo are less clarified. In the present study, we investigated whether ...
- ADULT AUTOIMMUNE DISEASE INDUCTION BY CHILDREN STRONG STRESS: -Cumulative childhood stress and autoimmune diseases in adults
Objective: To examine whether childhood traumatic stress increased the risk of developing autoimmune diseases as an adult. Methods: Retrospective cohort study of 15,357 adult health maintenance ...
- RHUPUS: -SYSTEMIC LUPUS ERYTHEMATOSUS & RHEUMATOID ARTHRITIS OVERLAP: -Overlap? between systemic lupus erythematosus and rheumatoid arthritis: is it real or just an illusion?
The association between rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) has been debated for many years. Based on their different genetic background and pathogenic mechanisms, it ...
- ISLET AUTOIMMUNITY TYPE 1 DIABETES: -Weight gain in early life predicts risk of islet autoimmunity in children with a first-degree relative with type 1 diabetes
OBJECTIVE In a prospective birth cohort study, we followed infants who had a first-degree relative with type 1 diabetes to investigate the relationship between early growth and infant feeding and the ...
- AUTOIMMUNITY: -Biomarkers for diagnosing and monitoring autoimmune diseases
Abstract The goal of studies of autoimmune disease biomarkers is to identity markers that fluctuate with disease development and severity, but then normalize following successful therapy. The ...
- NULL RESULTS: -Oral Cyclophosphamide for active scleroderma lung disease: A decision analysis
Background. Results from the recent Scleroderma Lung Study (SLS) show that oral cyclophosphamide (CYC) is better than placebo in preventing the progression of scleroderma-related interstitial lung ...
- AUTOIMMUNITY: -The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
ABSTRACTS The protein kinase C (PKC) family of serine-threonine kinases plays a central role in T lymphocyte activation. Here, we identify NR2F6, a nuclear zinc-finger orphan receptor, as a critical ...
