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- THERAPEUTIC AUTOIMMUNITY : - Vaccination with cytokines in autoimmune diseases
Authors: Laure Delavalle ab; Eric Assier ab; Anne Denys ab; Graldine Falgarone abc; Jean-Franois Zagury d; Sylvianne Muller e; Natacha Bessis ab; Marie-Christophe ...
- AUTOIMMUNITY: Overabundance of immune cells might trigger lupus: Study spots overactivity of genes that prevent cell death in those with autoimmune disease
Researchers from Saint Louis University report that a pile-up of superfluous immune cells might contribute to lupus, a finding which could point to new therapies for the autoimmune disease. "We're on ...
- AUTOIMMUNITY & GENETIC: Scientists identify genes linked to lupus in women
WINSTON-SALEM, N.C. – An international consortium of scientists has identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 ...
- AUTOIMMUNITY: Research suggests targeted treatment strategies for lupus
WINSTON-SALEM, N.C. – New research provides clues about the causes of lupus symptoms and suggests specific new targeted treatment strategies, according to Nilamadham Mishra, M.D., from Wake ...
- DRY EYE SYNDROME: Ocular surface disease index for the diagnosis of dry eye syndrome
Abstract Purpose: Evaluation of ocular surface disease index (OSDI) questionnaire for the diagnosis of dry eye syndrome. Methods: Sixty-eight patients admitted to the Ophthalmology Polyclinic of ...
- AMYLOIDOSIS, FMF & AR: Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis
OBJECTIVE To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the ...
- AUTOIMMUNITY: Rheumatoid arthritis and the complement system
Abstract Complement activation contributes to a pathological process in a number of autoimmune and inflammatory diseases, including rheumatoid arthritis (RA). In this review we summarize current ...
- AUTOIMMUNITY: VASCULITIS ANCA + : Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis
ABSTRACT & BACKGROUND We investigated circulating interleukin-18 concentrations in patients with ANCA-associated vasculitis (ASV) and healthy control subjects, and included a group of ...
- AUTOIMMUNITY BY OXIDATIVE STRESS IN LES: : Enhanced recognition of reactive oxygen species damaged human serum albumin by circulating systemic lupus erythematosus autoantibodies
ABSTRACT & BACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with autoantibodies as a near universal feature of the disease. Earlier investigations from our ...
- AUTOIMMUNITY: A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein
ABSTRACT & BACKGROUND: Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes ...
- AUTOIMMUNITY: Down-regulation of Fas-ligand mRNA in Sjögren's syndrome patients with enlarged exocrine glands
ABSTRACT & BACKGROUND We have reported that Sjögren's syndrome (SS) patients with enlarged exocrine glands (EEG) formerly referred to as Mikulicz's disease were defective with Fas-ligand (FasL) ...
- RHEUMATOLOGY & NEPHROLOGY: Does medical insurance matter in the progression to endstage renal disease among patients with lupus nephritis?
LUIS A. GONZÁLEZ, MD, Postdoctoral Research Fellow, The University of Alabama at Birmingham, 834 Faculty Office Tower, 510 – 20th Street South, Birmingham, Alabama 35294, USA; GRACIELA S. ...
- NEWS HOT TOPICS IN AUTOIMMUNE DISEASE: M.D. Anderson-led team reports possible key to autoimmune disease
A human peptide that acts as a natural antibiotic against invading microbes can also bind to the body’s own DNA and trigger an immune response in the absence of an infection, a research team led by ...
- GENETIC, AUTOIMMUNITY AND LUPUS: Research links genetic mutations to lupus
A gene discovered by scientists at Wake Forest University School of Medicine has been linked to lupus and related autoimmune diseases. The finding, reported in the current issue of Nature Genetics, ...
- SYSTEMIC LUPUS ERYTHEMATOSUS & THROMBOPHILIC RISK:Thrombosis risk in systemic lupus erythematosus: the role of thrombophilic risk factors
Objectives: Thromboembolic episodes are frequent manifestations of systemic lupus erythematosus (SLE). Although the presence of anti-phospholipid antibodies (aPL) is known to contribute to ...
