Abstract & Objective. Depletion of guanine and deoxyguanine nucleotides by inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) or introduction of 6-thioguanine nucleotide ...

Researchers from several universities of the USA and China have sequenced for the first time papaya genome; they have also identified the DNA of a transgenic organism for the first time. Prestigious ...

The mouse is a stalwart stand-in for humans in medical research, thanks to genomes that are 85 percent identical. But identical genes may behave differently in mouse and man, a study by University of ...

Logistics is a key part of life. Nutrition, tools and information constantly have to be transported from one place to another in cells. Scientists at the Max Planck Institute of Colloids and ...

One aquarium fish’s uncanny ability to regenerate essentially any cell type has given scientists a way to mimic cell loss that occurs in diseases such as Parkinson’s and diabetes then watch how the ...

Similarly to senescent fibroblasts, senescent normal human prostate (NHP) epithelial cells may promote tumor development, potentially through cell fusion, say US researchers. It is known that NHP ...

Internal browning of pears stored under low oxygen conditions is related to restricted gas exchange inside the fruit, according to a study published March 7th in the open-access journal PLoS ...

Abstract Microsurgical procedures such as free tissue transfer or replantations of amputated digits involve an obligatory ischemic period leading to regional tissue oedema, rhabdomyolysis, systemic ...

If the genome is the parts list of the human cell, certain proteins are the production managers, activating and deactivating genes as needed. Scientists funded by the National Institute of General ...

Researchers at the University of Warwick and the Indian Institute of Technology Kanpur have discovered that the mechanism that we rely on to transport iron safely through our blood stream can, in ...

The humble white button mushroom (Agaricus bisporus) has as much, and in some cases, more anti-oxidant properties than more expensive varieties. Although the button mushroom is the foremost ...

  UBC researchers have discovered some of the genetic secrets that enable pine and spruce trees to fight off pests and disease, uncovering critical new information about forests’ natural defense ...

ABSTRACT Most defective and unwanted cells die by apoptosis, an exquisitely controlled genetic programme for removing such cells without damaging the surrounding tissue. Once a cell has committed to ...

  Turning anthrax toxin into a cancer killer After binding to cell surface markers, the MMP-activated PA protein (PA-L1) is cleaved by surface associated MMPs, releasing the PA20 fragment. ...

PHILADELPHIA - For over 10 years, Wafik S. El-Deiry, MD, PhD, Professor of Medicine, Genetics, and Pharmacology at the University of Pennsylvania School of Medicine, has been pursuing a ...