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- HEART FAILURE: -Noninvasive ventilation in acute cardiogenic pulmonary edema
ABSTRACT Background Noninvasive ventilation (continuous positive airway pressure [CPAP] or noninvasive intermittent positive-pressure ventilation [NIPPV]) appears to be of benefit in the ...
- LIVER, MICROCIRCULATION, SEPSIS & SHOCK: - Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock
Abstract & Background: Dichloromethylenebisphosphonate (MDP) and gadolinium chloride (GdCl3) are substances frequently used for experimental depletion of Kupffer Cells (KC) in models of ...
- HEMORRHAGIC SHOCK, BLOOD SUBSTITUTES & CORONARY HEART DISEASE: Hemoglobin-based blood products linked to increased death, MI
Use of hemoglobin-based blood substitutes (HBBSs) is associated with increased risks for death and myocardial infarction (MI), a study by US-based researchers reveals. At least one such blood ...
- CRITICAL CARE: Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans
ABSTRACT Background The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the ...
- INFECTOLOGY & SEPSIS: Leukocyte adhesion in capillary-sized, p-selectin-coated micropipettes
Objective: Leukocyte retention in lung capillaries is observed in normal physiology and following a bacterial infection. It has been hypothesized that cells either become mechanically trapped or ...
- VENTILATION IN CRITICAL CARE: Effect of positive expiratory pressure and type of tracheal cuff on the incidence of aspiration in mechanically ventilated patients in an intensive care unit *.
Objective: To test the effects of positive expiratory pressure on the leakage of fluid around cuffs of different tracheal tubes, in mechanically ventilated patients and in a benchtop model. Design: ...
- CRITICAL CARE: How decisions are made to admit patients to medical intensive care units (MICUs): A survey of MICU directors at academic medical centers across the United States.
Objective: To determine how medical intensive care unit (MICU) admission decisions are made at U.S. academic MICUs and to learn how these practices compare with the recommendations of the Society of ...
- CRITICAL CARE: Validation of the mortality in emergency department sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS) *.
Objective: To prospectively and externally validate the Mortality in Emergency Department Sepsis (MEDS) score as a predictor of 28-day mortality in patients who present to the emergency department ...
- HEMODYNAMICS IN CRITICAL CARE: Effects of changes in vascular tone on the agreement between pulse contour and transpulmonary thermodilution cardiac output measurements within an up to 6-hour calibration-free period
Objectives: To examine whether the agreement between pulse contour and transpulmonary thermodilution cardiac index (CI) measurements is altered by changes in vascular tone within an up to 6-hr ...
- CRITICAL RESPIRATORY CARE: Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical trials: Experience at the Massachusetts General Hospital *.
Background: Noninvasive positive-pressure ventilation (NPPV) has been shown to be effective in select patients enrolled in clinical trials. However, few data are available on the use of NPPV as ...
- CRITICAL CARE: SEPSIS & (G-CSF): Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock.
Objective: To investigate the effect of early administration of granulocyte colony-stimulating factor (G-CSF) on hospital mortality in nonneutropenic patients with septic shock, excluding patients ...
- CRITICAL RESPIRATORY CARE: Detecting ineffective triggering in the expiratory phase in mechanically ventilated patients based on airway flow and pressure deflection: Feasibility of using a computer algorithm *.
Objective: Ineffective triggering (IT) is the most common manifestation of patient-ventilator asynchrony in mechanically ventilated patients. IT in the expiratory phase (ITE) accounts for the ...
- QUALITY IN CRITICAL CARE: Perceptions of cost constraints, resource limitations, and rationing in United States intensive care units: Results of a national survey.
OBJECTIVE: To examine cost constraints, resource limitations, and rationing within U.S. intensive care units (ICUs) as perceived by ICU clinicians and the roles of ICU physician and nurse directors ...
- EMERGENTOLOGY & CRITICAL CARE: Characteristics and outcomes of patients receiving a medical emergency team review for acute change in conscious state or arrhythmias
Objective: To describe the characteristics and outcomes of patients receiving a medical emergency team (MET) review for the MET syndromes of acute change in conscious state or arrhythmia and to ...
- CRITICAL CARE & MANAGEMENT INTERMITTENT OR CONTINOUS RENAL REPLACEMENT THERAPY: Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: A meta-analysis *.
Objective: To appraise the literature on the effect of initial renal replacement therapy (RRT) modality on clinical outcomes. Design: Systematic review and meta-analysis. Setting: Academic medical ...
