Annals ofDiabetes

Volume: 4 - Number: 32 - October 15, 2004

Outstanding

The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia

The Metabolic Syndrome and Antioxidant Concentrations: Findings From the Third National Health and Nutrition Examination Survey

Increased ß-Cell Apoptosis Prevents Adaptive Increase in ß-Cell Mass in Mouse Model of Type 2 Diabetes: Evidence for Role of Islet Amyloid Formation Rather Than Direct Action of Amyloid

Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (Ay/a) Obese Mice

Brief Genetics Reports

Level of an Advanced Glycated End Product Is Genetically Determined: A Study of Normal Twins

Complication's

Two Phases of Nitrergic Neuropathy in Streptozotocin-Induced Diabetic Rats

Sensory Neurons With Activated Caspase-3 Survive Long-Term Experimental Diabetes

Neurotrophin-3 Prevents the Proximal Accumulation of Neurofilament Proteins in Sensory Neurons of Streptozocin-Induced Diabetic Rats

S100B-RAGE-Mediated Augmentation of Angiotensin II-Induced Activation of JAK2 in Vascular Smooth Muscle Cells Is Dependent on PLD3

B-Type Natriuretic Peptide Prevents Acute Hypertrophic Responses in the Diabetic Rat Heart: Importance of Cyclic GMP

Effects of Rosuvastatin on Nitric Oxide–Dependent Function in Aorta and Corpus Cavernosum of Diabetic Mice: Relationship to Cholesterol Biosynthesis Pathway Inhibition and Lipid Lowering

Genetic

Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor

Impaired Cathepsin L Gene Expression in Skeletal Muscle Is Associated With Type 2 Diabetes

Genome-Wide Linkage Analysis of Serum Adiponectin in the Pima Indian Population

Properties of Normal and Mutant Recombinant Human Ketohexokinases and Implications for the Pathogenesis of Essential Fructosuria

Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations

Immunology and Transplantation

Critical Roles of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Type 1 Diabetes

DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation

Immunologic Activity in the Small Intestinal Mucosa of Pediatric Patients With Type 1 Diabetes

Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting ß-Cells

Islet studies

Increased ß-Cell Apoptosis Prevents Adaptive Increase in ß-Cell Mass in Mouse Model of Type 2 Diabetes: Evidence for Role of Islet Amyloid Formation Rather Than Direct Action of Amyloid

An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures

Metabolism

Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Higher Insulin Concentrations Are Required to Suppress Gluconeogenesis Than Glycogenolysis in Nondiabetic Humans

Regulation and Function of the Muscle Glycogen-Targeting Subunit of Protein Phosphatase 1 (GM) in Human Muscle Cells Depends on the COOH-Terminal Region and Glycogen Content

Obesity studies

Differential Influences of Peroxisome Proliferator–Activated Receptors and - on Food Intake and Energy Homeostasis

Hyperphagic Effects of Brainstem Ghrelin Administration

Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (Ay/a) Obese Mice

Pathophysiology

The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia

Peroxisome Proliferator-Activated Receptor (PPAR)- Activation Prevents Diabetes in OLETF Rats: Comparison With PPAR- Activation

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes: Evidence That Insulin Resistance Is Associated With a Disturbed Antioxidant Defense Mechanism

The Metabolic Syndrome and Antioxidant Concentrations: Findings From the Third National Health and Nutrition Examination Survey

Signal transduction

A Novel Insulin Analog With Unique Properties: LysB3,GluB29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes