Annals ofDiabetes

Volume: 4 - Number: 34 - December 15, 2004

Outstanding

Articles

Identification of a ß-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

Complication's

Intermittent High Glucose Enhances Apoptosis Related to Oxidative Stress in Human Umbilical Vein Endothelial Cells: The Role of Protein Kinase C and NAD(P)H-Oxidase Activation

Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice

Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits

Leptin and Wound Inflammation in Diabetic ob/ob Mice: Differential Regulation of Neutrophil and Macrophage Influx and a Potential Role for the Scab as a Sink for Inflammatory Cells and Mediators

Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance?: The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study

Genetic

Linkage Analysis of a Composite Factor for the Multiple Metabolic Syndrome: The National Heart, Lung, and Blood Institute Family Heart Study

Association of Solute Carrier Family 12 (Sodium/Chloride) Member 3 With Diabetic Nephropathy, Identified by Genome-Wide Analyses of Single Nucleotide Polymorphisms

Permanent Neonatal Diabetes Caused by Glucokinase Deficiency: Inborn Error of the Glucose-Insulin Signaling Pathway

Immunology and Transplantation

Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes–Specific GAD65Abs

Target Cell Expression of Suppressor of Cytokine Signaling-1 Prevents Diabetes in the NOD Mouse

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

Islets cell studies

Parathyroid Hormone–Related Protein Induces Insulin Expression Through Activation of MAP Kinase–Specific Phosphatase-1 That Dephosphorylates c-Jun NH2-Terminal Kinase in Pancreatic ß-Cells

Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets

Obesity Studies

Coordinated Upregulation of Oxidative Pathways and Downregulation of Lipid Biosynthesis Underlie Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile

Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice

Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII

Pathophysiology

Identification of Subjects with Insulin Resistance and ß-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome

Contribution of Elevated Free Fatty Acid Levels to the Lack of Glucose Effectiveness in Type 2 Diabetes

Prevalence and Clinicopathological Characteristics of Islet Amyloid in Chinese Patients With Type 2 Diabetes

Extracellular Glucose in Rat Ventromedial Hypothalamus During Acute and Recurrent Hypoglycemia

Counterregulatory Hormone and Symptom Responses to Insulin-Induced Hypoglycemia in the Postprandial State in Humans

Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor

Perspectives in Diabetes

Hypothesis: Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome

Signal transduction

Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice