Annals ofDiabetes

Volume: 5 - Number: 35 - January 15, 2005

Outstanding

Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose

Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

Insulin is Required for Prandial Ghrelin Suppression in Humans

Brief Genetics Reports

The Endotoxin Receptor TLR4 Polymorphism Is Not Associated With Diabetes or Components of the Metabolic Syndrome

The Human MC4R Promoter: Characterization and Role in Obesity

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

Complication's

Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose

Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes

Diabetes perspective

Microvascular Complications of Impaired Glucose Tolerance

Genetic

Permanent Neonatal Diabetes Caused by Glucokinase Deficiency: Inborn Error of the Glucose-Insulin Signaling Pathway

Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization

Regulation of Apolipoprotein M Gene Expression by MODY3 Gene Hepatocyte Nuclear Factor-1: Haploinsufficiency Is Associated With Reduced Serum Apolipoprotein M Levels

Immunology and Transplantation

Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo After Transplantation in Rats

Islets cell studies

On-Line Monitoring of Apoptosis in Insulin-Secreting Cells

Metabolism

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor- Coactivator-1 and Peroxisome Proliferator-Activated Receptor- in Skeletal Muscle

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

A Mammalian Protein Homologous to Fructosamine-3-Kinase Is a Ketosamine-3-Kinase Acting on Psicosamines and Ribulosamines but not on Fructosamines

Obesity Studies

Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes

Insulin is Required for Prandial Ghrelin Suppression in Humans

Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System

Pathophysiology

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

Signal transduction

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement