Absortion, Distribution, Metabolism and Excretion
Altered Hepatobiliary Disposition of Acetaminophen Glucuronide in Isolated Perfused Livers from Multidrug Resistance-Associated Protein 2-Deficient TR- Rats
Tasosartan, Enoltasosartan, and Angiotensin II Receptor Blockade: The Confounding Role of Protein Binding
Chronic Intragastric Infusion of Ethanol-Containing Diets Induces CYP3A9 While Decreasing CYP3A2 in Male Rats
Right Heart Failure Impairs Hepatic Elimination of p-Nitrophenol without Inducing Changes in Content or Latency of Hepatic UDP-Glucuronosyltransferases
Evaluation of Route of Input on the Hepatic Disposition of Diazepam
5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese Populations Related to CYP2C19 Gene Dose and Individual Ethnicity
Cardiovascular
Enhanced EndothelinA Receptor-Mediated Calcium Mobilization and Contraction in Organ Cultured Porcine Coronary Arteries
Prevention of Arterial Thrombosis by Intravenously Administered Platelet P2T Receptor Antagonist AR-C69931MX in a Canine Model
Tamoxifen Acutely Relaxes Coronary Arteries by an Endothelium-, Nitric Oxide-, and Estrogen Receptor-Dependent Mechanism
A Pyrroline Derivative of Mexiletine Offers Marked Protection against Ischemia/Reperfusion-Induced Myocardial Contractile Dysfunction
Endothelin Receptor Antagonism Does Not Prevent the Development of In Vivo Glyceryl Trinitrate Tolerance in the Rat
Rationale for the Combination of PGE1 and S-Nitroso-glutathione to Induce Relaxation of Human Penile Smooth Muscle
Modulation of Nitric-Oxide Synthase by Nicotine
Interactions of the 5-Hydroxytryptamine 3 Antagonist Class of Antiemetic Drugs with Human Cardiac Ion Channels
Protective Effect of Omapatrilat, a Vasopeptidase Inhibitor, on the Metabolism of Bradykinin in Normal and Failing Human Hearts
An alpha1A/alpha1L-Adrenoceptor Mediates Contraction of Canine Subcutaneous Resistance Arteries
Endogenous Bradykinin and the Renin and Pressor Responses to Furosemide in Humans
Glycoprotein IIb/IIIa Receptor Number and Occupancy during Chronic Administration of an Oral Antagonist
Losartan Improves Recovery of Contraction and Inhibits Transient Inward Current in a Cellular Model of Cardiac Ischemia and Reperfusion
Characterization of Mibefradil Block of the Human Heart Delayed Rectifier hKv1.
Potent and Reversible Effects of ATI-2001 on Atrial and Atrioventricular Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart
Nitric Oxide Stimulatory and Endothelial Protective Effects of Idoxifene, a Selective Estrogen Receptor Modulator, in the Splanchnic Artery of the Ovariectomized Rat
Functional Evidence of a Constitutively Active Population of 1D-Adrenoceptors in Rat Aorta
Inhibition of Endothelial Cell Activation by Nitric Oxide Donors
The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Endopolyploidy in Chinese Hamster Ovary Cells
delta-Opioid Receptors Are More Efficiently Coupled to Adenylyl Cyclase Than to L-Type Ca2+ Channels in Transfected Rat Pituitary Cells
Cross-Chimeric Analysis of Selectivity of Secretin and VPAC1 Receptor Activation
Chemotherapy, Antibiotics and Gene Therapy
Efficacy of LGD1069 (Targretin), a Retinoid X Receptor-Selective Ligand, for Treatment of Uterine Leiomyoma
Sensitivity of Myelomonocytic Leukemia Cells to Arsenite-Induced Cell Cycle Disruption, Apoptosis, and Enhanced Differentiation Is Dependent on the Inter-Relationship between Arsenic Concentration, Duration of Treatment, and Cell Cycle Phase
Semiphysiological Model for the Time Course of Leukocytes after Varying Schedules of 5-Fluorouracil in Rats
Hypoglycemic Effect of Insulin-Transferrin Conjugate in Streptozotocin-Induced Diabetic Rats
Beneficial Insulin-Sensitizing and Vascular Effects of S15261 in the Insulin-Resistant JCR:LA-cp Rat
Tuberoinfundibular Peptide (7-39) [TIP(7-39)], a Novel, Selective, High-Affinity Antagonist for the Parathyroid Hormone-1 Receptor with No Detectable Agonist Activity
Gastroenterology, Hepatic, Renal and Lung
Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
Role of Inducible Nitric-Oxide Synthase in Regulation of Whole-Cell Current in Lung Epithelial Cells
Excitatory and Inhibitory Actions of Isoprostanes in Human and Canine Airway Smooth Muscle
Signaling Mechanisms Coupled to Presynaptic A1- and H3-Receptors in the Inhibition of Cholinergic Contractile Responses of the Guinea Pig Ileum
A Turnover Model of Irreversible Inhibition of Gastric Acid Secretion by Omeprazole in the Dog
Polarized Efflux of Mono- and Diacid Metabolites of ME3229, an Ester-Type Prodrug of a Glycoprotein IIb/IIIa Receptor Antagonist, in Rat Small Intestine
Inflammation and Immunopharmacology
Identification of R146225 as a Novel, Orally Active Inhibitor of Interleukin-5 Biosynthesis
Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats
Neuropharmacology
Long-Lasting Facilitation of 4-Amino-n-[2,3-3H]butyric Acid ([3H]GABA) Release from Rat Hippocampal Slices by Nicotinic Receptor Activation
Effects of Tetraethylammonium Analogs on Apoptosis and Membrane Currents in Cultured Cortical Neurons
Site of Action of Lubeluzole on Voltage-Sensitive Ca2+ Channels in Isolated Dorsal Root Ganglion Cells of the Rat: Influence of pH
Analgesic Synergy between Topical Lidocaine and Topical Opioids
Alterations of N-Methyl-D-aspartate Receptor Properties after Chemical Ischemia
Oral Cocaine Pharmacokinetics and Pharmacodynamics in a Cumulative-Dose Regimen: Pharmacokinetic-Pharmacodynamic Modeling of Concurrent Operant and Spontaneous Behavior within an Operant Context
Down-Regulation of Benzodiazepine Binding to alpha5 Subunit-Containing gamma-Aminobutyric AcidA Receptors in Tolerant Rat Brain Indicates Particular Involvement of the Hippocampal CA1 Region
The In Vitro Ethanol Sensitivity of Hippocampal Synaptic gamma-Aminobutyric AcidA Responses Differs in Lines of Mice and Rats Genetically Selected for Behavioral Sensitivity or Insensitivity to Ethanol
Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway
Nitric Oxide and NK1-Tachykinin Receptors in Cyclophosphamide-Induced Cystitis, in Rats
Perspectives
Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action
Multiple Central Nervous System Targets for Eliciting Beneficial Effects on Memory and Cognition
