Annals ofPharmacology

Volume: 3 - Number: 23 - November 15, 2003

Outstanding

Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism

The Gastroprokinetic and Antiemetic Drug Metoclopramide Is a Substrate and Inhibitor of Cytochrome P450 2D7

Incorporating Measures of Variability and Uncertainty into the Prediction of in Vivo Hepatic Clearance from in Vitro Data

Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein Efflux System

Antifungal

Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives

Antineoplasic drugs

Glutathione and Mercapturic Acid Conjugates of Sulofenur and Their Activity against a Human Colon Cancer Cell Line

Biomarkers

Urinary Naphthalene Mercapturates as Biomarkers of Exposure and Stereoselectivity of Naphthalene Epoxidation

Clearance

Incorporating Measures of Variability and Uncertainty into the Prediction of in Vivo Hepatic Clearance from in Vitro Data

N-Glucuronidation of Some 4-Arylalkyl-1H-Imidazoles by Rat, Dog, and Human Liver Microsomes

Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency

Conjugation

Increase in Rat Liver UDP-Glucuronosyltransferase mRNA by Microsomal Enzyme Inducers that Enhance Thyroid Hormone Glucuronidation

Glucuronidation of Acetaminophen Catalyzed by Multiple Rat Phenol UDP-Glucuronosyltransferases

Cytochrome P450

(+)-N-3-Benzyl-Nirvanol and ()-N-3-Benzyl-Phenobarbital: New Potent and Selective in Vitro Inhibitors of CYP2C20

Phosphonate O-Deethylation of [4-(4-Bromo-2-Cyano-Phenylcarbamoyl) Benzyl]-Phosphonic Acid Diethyl Ester, a Lipoprotein Lipase-Promoting Agent, Catalyzed by Cytochrome P450 2C8 and 3A4 in Human Liver Microsomes

The Gastroprokinetic and Antiemetic Drug Metoclopramide Is a Substrate and Inhibitor of Cytochrome P450 2D7

Endorphins

Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein Efflux System

Induction

Induction of CYP1A1 and CYP1B1 in T-47D Human Breast Cancer Cells by Benzo[a]pyrene Is Diminished by Arsenite

Postnatal Expression and Induction by Pregnenolone-16-Carbonitrile of the Organic Anion-Transporting Polypeptide 2 in Rat Liver

Lipids

Structural Characterization of in Vivo Rat Glutathione Adducts and a Hydroxylated Metabolite of Simvastatin Hydroxy Acid

Metabolism

In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide

Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism

Microsomes

The Alkaloid Rutaecarpine Is a Selective Inhibitor of Cytochrome P450 1A in Mouse and Human Liver Microsomes

Pharmacokinetic

The Pharmacokinetic Determinants of the Frequency and Pattern of Intravenous Cocaine Self-administration in Rats by Pharmacokinetic Modeling

Poison

Chiral Pharmacokinetics and Inversion of Enantiomers of a New Quinoxaline Topoisomerase II Poison in the Rat