Annals ofPharmacology

Volume: 3 - Number: 24 - December 15, 2003

Outstanding

Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Mechanisms Underlying Nonsteroidal Anti-Inflammatory Drug-Induced p27Kip1 Expression

Synthesis and Evaluation of a New Class of Nifedipine Analogs with T-Type Calcium Channel Blocking Activity

Anti-inflammatory drugs

Mechanisms Underlying Nonsteroidal Anti-Inflammatory Drug-Induced p27Kip1 Expression

Article

Activation and Inhibition of G Proteins by Lipoamines

Calcium channels blockers

Synthesis and Evaluation of a New Class of Nifedipine Analogs with T-Type Calcium Channel Blocking Activity

Single-Channel Pharmacology of Mibefradil in Human Native T-Type and Recombinant Cav3.2 Calcium Channels

Cytochrome P450

Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

Regulation of Pulmonary and Hepatic Cytochrome P4501A Expression in the Rat by Hyperoxia: Implications for Hyperoxic Lung Injury

Extensive review

Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway

Pivalate-Generating Prodrugs and Carnitine Homeostasis in Man

Homocysteine Determinants and the Evidence to What Extent Homocysteine Determines the Risk of Coronary Heart Disease

Protein Nitration in Cardiovascular Diseases

Inducers

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

Opioid

Opioid Agonists Differentially Regulate µ-Opioid Receptors and Trafficking Proteins in Vivo

Oxidative stress

Enhancement of Metabolic Oxidative Stress-Induced Cytotoxicity by the Thioredoxin Inhibitor 1-Methylpropyl 2-Imidazolyl Disulfide Is Mediated through the ASK1-SEK1-JNK1 Pathway

Vesnarinone Causes Oxidative Damage by Inhibiting Catalase Function through Ceramide Action in Myeloid Cell Apoptosis

Perspectives in Pharmacology

Desensitization of Cannabinoid-Mediated Presynaptic Inhibition of Neurotransmission Between Rat Hippocampal Neurons in Culture

Protein kinasa

Commitment of Activated T Cells to Secondary Responsiveness Is Enhanced by Signals Mediated by cAMP-Dependent Protein Kinase A-I

Identification of PKC Isoform-Specific Effects in Cardiac Myocytes Using Antisense Phosphorothioate Oligonucleotides

Receptors

Differential Response of Estrogen Receptors and to SP500263, a Novel Potent Selective Estrogen Receptor Modulator

Activation of cAMP-Dependent Protein Kinase Suppresses the Presynaptic Cannabinoid Inhibition of Glutamatergic Transmission at Corticostriatal Synapses

Increased Sensitivity to Nicotine-Induced Seizures in Mice Expressing the L250T 7 Nicotinic Acetylcholine Receptor Mutation

Regulation

Regulation of Cyclooxygenase-2 Expression by Phospholipase D in Human Amnion-Derived WISH Cells

Toxicity

Multiple Interference of Anthracyclines with Mitochondrial Creatine Kinases: Preferential Damage of the Cardiac Isoenzyme and Its Implications for Drug Cardiotoxicity