Absortion, Distribution, Metabolism and Excretion
A Biosynthetic Pathway Generating 12-Hydroxy-5,8,14-eicosatrienoic Acid from Arachidonic Acid Is Active in Mouse Skin Microsomes
Evaluation of Tributyrin Lipid Emulsion with Affinity to Low-Density Lipoprotein: Pharmacokinetics in Adult Male Wistar Rats and Cellular Activity on Caco-2 and HepG2 Cell Lines
Behavioral pharmacology
Depressive-Like Effects of the -Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
Cardiovascular
A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor Agonist Reverses Endothelial Dysfunction in Diabetic (db/db-/-) Mice
ARD-353 [4-((2R,5S)-4-(R)-(4-Diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic Acid], A Novel Nonpeptide Receptor Agonist, Reduces Myocardial Infarct Size without Central Effects
Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial KATP Channels, Blocks Sarcolemmal KATP Channels, and Confers Cardioprotection
Blockade of Electron Transport before Cardiac Ischemia with the Reversible Inhibitor Amobarbital Protects Rat Heart Mitochondria
Chronic Ethanol Consumption Enhances Phenylephrine-Induced Contraction in the Isolated Rat Aorta
Dosing Time-Dependent Effect of Temocapril on the Mortality of Stroke-Prone Spontaneously Hypertensive Rats
Hyperlipidemia Attenuates the Infarct Size-Limiting Effect of Ischemic Preconditioning: Role of Matrix Metalloproteinase-2 Inhibition
Cellular y Molecular
3-O-Acetyl-11-keto-boswellic Acid Decreases Basal Intracellular Ca2+ Levels and Inhibits Agonist-Induced Ca2+ Mobilization and Mitogen-Activated Protein Kinase Activation in Human Monocytic Cells
Constitutive Activity and Inverse Agonism at the M2 Muscarinic Acetylcholine Receptor
Erythropoietin Receptor Signal Transduction Requires Protein Geranylgeranylation
HIV Protease Inhibitors: Suppression of Insulin Secretion by Inhibition of Voltage-Dependent K+ Currents and Anion Currents
Chemotherapy, Antibiotics and Gene Therapy
Hpr6 (Heme-1 Domain Protein) Regulates the Susceptibility of Cancer Cells to Chemotherapeutic Drugs
Gastroenterology, Hepatic, Renal and Lung
Energy Homeostasis and Gastric Emptying in Ghrelin Knockout Mice
Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating KATP Channels
Expression and Response to Angiotensin-Converting Enzyme Inhibition of Matrix Metalloproteinases 2 and 9 in Renal Glomerular Damage in Young Transgenic Rats with Renin-Dependent Hypertension
Inflammation and immunepharmacology
Activation of the Adenosine A3 Receptor in RAW 264.7 Cells Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor- Release by Reducing Calcium-Dependent Activation of Nuclear Factor-B and Extracellular Signal-Regulated Kinase 1/2
Antiexudative Effects of Opioids and Expression of - and - Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide
Blockade of Nuclear Factor-B Signaling Pathway and Anti-Inflammatory Activity of Cardamomin, a Chalcone Analog from Alpinia conchigera
Neuropharmacology
Characterization of Prejunctional Serotonin Receptors Modulating [3H]Acetylcholine Release in the Human Detrusor
Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D3 Receptor Activation
Evaluation of Drug Penetration into the Brain: A Double Study by in Vivo Imaging with Positron Emission Tomography and Using an in Vitro Model of the Human Blood-Brain Barrier
Toxicology
4,4\'-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat
Arsenic Trioxide Induces Apoptosis of Human Monocytes during Macrophagic Differentiation through Nuclear Factor-B-Related Survival Pathway Down-Regulation
Deltamethrin, a Pyrethroid Insecticide, Is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons
