Annals ofPharmacology

Volume: 11 - Number: 108 - January 15, 2011

Outstanding

Behaviour Pharmacology

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/?-Opioid Receptor Agonists

Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/?-Opioid Receptor Ligands: Implications for Therapeutic Applications

Cardiovascular

Involvement of Cyclooxygenase-2 in Carbachol-Induced Positive Inotropic Response in Mouse Isolated Left Atrium

Sensing of Blood Pressure Increase by Transient Receptor Potential Vanilloid 1 Receptors on Baroreceptors

Inhibition of Thromboxane A2-Induced Arrhythmias and Intracellular Calcium Changes in Cardiac Myocytes by Blockade of the Inositol Trisphosphate Pathway

Inhibition of Endothelin ETB Receptor System Aggravates Neointimal Hyperplasia after Balloon Injury of Rat Carotid Artery

20-125Iodo-14,15-Epoxyeicosa-5(Z)-enoic Acid: a High-Affinity Radioligand Used to Characterize the Epoxyeicosatrienoic Acid Antagonist Binding Site

Cellular y Molecular

Effect of the Calcimimetic R-568 [3-(2-Chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on Correcting Inactivating Mutations in the Human Calcium-Sensing Receptor

Omigapil Ameliorates the Pathology of Muscle Dystrophy Caused by Laminin-?2 Deficiency

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Heme Oxygenase-2 Deletion Causes Endothelial Cell Activation Marked by Oxidative Stress, Inflammation, and Angiogenesis

Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with G?? Binding

Endocrine and diabetes

Contrasting Effects of Allosteric and Orthosteric Agonists on M1 Muscarinic Acetylcholine Receptor Internalization and Down-regulation

Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible ?-Cell Hyperplasia and Hyperglucagonemia

Highlighted papers

Enterobacteria Regulate Hepatic Bile Acid Synthesis via Fibroblast Growth Factor

Interplay Between Eicosanoids and Heme Oxygenase in Metabolic Syndrome

Perspectives in Pharmacology

Quantitative Pharmacology or Pharmacokinetic Pharmacodynamic Integration Should Be a Vital Component in Integrative Pharmacology

Review Articles

Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms

Pharmacogenomic Discovery Using Cell-Based Models

Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility