Annals ofGastroenterology & Hepatology

Volume: 5 - Number: 51 - September 15, 2007

Outstanding

Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads

Luminal leptin activates mucin-secreting goblet cells in the large bowel

Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors

Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

Hormones and Signal

Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads

Luminal leptin activates mucin-secreting goblet cells in the large bowel

Inflammation/immunity/mediators

Febrile-range temperature but not heat shock augments the acute phase response to interleukin-6 in human hepatoma cells

Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis

INNOVATIVE METHODOLOGY

Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans

Liver and Bile Ducts

Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione

Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells

Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts

Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt

Motility and neuroregulation

Spontaneous electrical rhythmicity and the role of the sarcoplasmic reticulum in the excitability of guinea pig gallbladder smooth muscle cells

Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators

Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity

Mucosal biology

Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection

Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice

Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors

Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L– effector memory T cells

Themes

Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation

Translational physiology

Hedgehog signaling maintains resident hepatic progenitors throughout life

Gain of allelic gene expression for IGF-II occurs frequently in Barrett\'s esophagus