Annals ofHematology

Volume: 4 - Number: 24 - February 15, 2004

Outstanding

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

Lack of 2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

Murky waters for MRD detection in AML: flighty FLT3/ITDs

Brief Reports

Phagocytosing neutrophils down-regulate the expression of chemokine receptors CXCR1 and CXCR2

Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells

Polymorphisms of the tumor necrosis factor- gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma

Prolongation of cardiac repolarization by arsenic trioxide

Clinical and Therapeutics Observations

Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia

Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia results of the prospective multicenter LALA-94 trial

Gene Therapy

Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy

Pharmacologically regulated in vivo selection in a large animal

Hematopoiesis

Polyclonal long-term repopulating stem cell clones in a primate model

Hemostasis, Thrombosis and Vascular Biology

Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration

Lack of 2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction

Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype

Normal Arp2/3 complex activation in platelets lacking WASp

P2X1-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen

Platelets, circulating tissue factor, and fibrin colocalize in ex vivo thrombi: real-time fluorescence images of thrombus formation and propagation under defined flow conditions

Immunobiology

Latent cytomegalovirus down-regulates major histocompatibility complex class II expression on myeloid progenitors

Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4+/CD25+ T cells

Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer

Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo

Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization

Mouse CD11c+ B220+ Gr1+ plasmacytoid dendritic cells develop independently of the T-cell lineage

Myeloid blood CD11c+ dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes

Into the blood

Murky waters for MRD detection in AML: flighty FLT3/ITDs

Novel treatment for Diamond-Blackfan anemia?

Neoplasia

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

Reviews

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect