Annals ofHematology

Volume: 4 - Number: 31 - September 15, 2004

Outstanding

Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation

Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells

Stem cell transplantation for chronic myeloid leukemia in children

Build it and they will come (or will they?)

Chemokines

RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement

TGF inhibits LPS-induced chemokine mRNA stabilization

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

Clinical and Therapeutics Observations

Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation

Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia

Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells

Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response

Stem cell transplantation for chronic myeloid leukemia in children

Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMAAML-10 trial

Gene Therapy

Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared with EBV-reactive CD8 T cells

Hematopoiesis

Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

NMDA receptor–mediated regulation of human megakaryocytopoiesis

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

Transcription activation function of C/EBP is required for induction of granulocytic differentiation

Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

Stat5 expression is critical for mast cell development and survival

Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation

Hemostasis, Thrombosis and Vascular Biology

Platelet 21 integrin activation: contribution of ligand internalization and the 2-cytoplasmic domain

Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized

Into the blood

Leukemic cell resistance: targeting needed beyond MDR-1

Chronic graft-versus-host disease (cGVHD) is more frequent due to changes in the practice of stem cell transplantation (SCT)

Build it and they will come (or will they?)

Novel functional defect in factor V deficiency

What genes do Shiga toxins target?

Extending the repertoire of Epo action

DAG signaling taught us a lesson: what diverges can converge

Neutrophils and the protein C pathway

PlGF: a link between inflammation and angiogenesis in sickle disease

Perspectives

New insights into the structural basis of integrin activation

Review

Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia