Annals ofHematology

Volume: 6 - Number: 53 - August 15, 2006

Outstanding

Identification and characterization of undifferentiated mast cells in mouse bone marrow

Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis

Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2

Endothelial apoptosis induced by inhibition of integrins v3 and v5 involves ceramide metabolic pathways

Gene Therapy

Systemic protein delivery by muscle-gene transfer is limited by a local immune response

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis

An inducible caspase 9 safety switch for T-cell therapy

Brief report Failure of SCID-X1 gene therapy in older patients

Hematopoiesis

Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-2

A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2

Identification and characterization of undifferentiated mast cells in mouse bone marrow

Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis

Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development

Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2

Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Sema4D induces angiogenesis through Met recruitment by Plexin B2

Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease

Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature

The 3 subunit of the integrin IIb3 regulates IIb-mediated outside-in signaling

Endothelial apoptosis induced by inhibition of integrins v3 and v5 involves ceramide metabolic pathways

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site

Selective impairment of platelet activation to collagen in the absence of GATA1

Immunobiology

Negative thymocyte selection to HERV-K18 superantigens in humans

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells