Annals ofHematology

Volume: 7 - Number: 59 - February 15, 2007

Outstanding

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity

Neoplasia

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice

High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos

A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)

Activation of -diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

Brief report The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome /myeloproliferative disease

Brief report Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML

Brief report Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

Brief report Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

Phagocytes

C/EBP functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (FcR, CD89) gene promoter

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity

Red Cells

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic -like globin genes in vivo

Identification of the receptor scavenging hemopexin-heme complexes

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)