Annals ofHematology

Volume: 7 - Number: 62 - May 15, 2007

Outstanding

ROS: double-edged sword for leukemic cells

Microtubules, leukemia, and cough syrup

Could shear stress be the answer?

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Chemokines

Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G

Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4–/– chimeric mice

Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFB

Chemokine and chemokine receptor expression during colony stimulating factor-1–induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1) in osteoclastogenesis in vivo and in vitro

Clinical trials and observations

Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Gene Therapy

Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen

Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation

Hematopoiesis

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

Into the blood

ROS: double-edged sword for leukemic cells

Allo attack on amyloidosis

Clues to lymphoma\'s cellular origin

Hematopoietic stem cells, explicitly

Microtubules, leukemia, and cough syrup

Classical Hodgkin lymphoma: an epigenetically determined disease?

Could shear stress be the answer?

Reviews

Recent insights into the role of Notch signaling in tumorigenesis