Annals ofHematology

Volume: 7 - Number: 65 - August 15, 2007

Outstanding

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation

Do hemophilia carriers bleed? Yes.

Brief report New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls

Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children\'s Oncology Group

Clinical trials and observations

Brief report Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety

Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older

Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children\'s Oncology Group

Hematopoiesis

Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment

Hemostasis, thrombosis, and vascular biology

Brief report New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls

Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells

Immunobiology

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

FOG-1 represses GATA-1-dependent FcRI -chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features

Into the blood

CAPitalizing on AAV

Do hemophilia carriers bleed? Yes.

Does JAK2 1849G>T initiate polycythemia vera?

Escaping inhibition by self-mutation

Neoplasia

Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas

Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis

Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype

Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders

Phagocytes

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation

PLENARY PAPERS

EBV-associated mononucleosis leads to long-term global deficit in T-cell responsiveness to IL-15.

Red Cells

Brief report Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)