Annals ofHematology

Volume: 8 - Number: 70 - January 15, 2008

Outstanding

Drifting precariously due to lost tyrosines

Brief report Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-B–dependent manner in Churg-Strauss syndrome

Chest mass and anemia

"Hemostasis, thrombosis and vascular biology"

Brief report A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?

Blood work

Chest mass and anemia

Clínical trials and olbservations

Brief report Durable responses to imatinib in patients with PDGFRB fusion gene–positive and BCR-ABL–negative chronic myeloproliferative disorders

Brief report Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-B–dependent manner in Churg-Strauss syndrome

Gene Therapy

Foamy virus–mediated gene transfer to canine repopulating cells

Hematopoiesis

Brief report Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+4f/f mice are hematopoietic cell autonomous

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis

Immunology

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Hematopoietic stem cell–engrafted NOD/SCID/IL2Rnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

Into the blood

Drifting precariously due to lost tyrosines

Genomic loss is our gain

Neoplasia

Association of a novel regulatory polymorphism (–938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia

Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction

EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival

RED CELLS

Brief report Monoclonal immunoglobulin with antitransferrin activity: a rare cause of hypersideremia with increased transferrin saturation

Brief report Reversal of cardiac complications by deferiprone and deferoxamine combination therapy in a patient affected by a severe type of juvenile hemochromatosis (JH)

Transplantation

Brief report Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning