Annals ofHematology

Volume: 8 - Number: 72 - March 15, 2008

Outstanding

Phospholipase C, calcium, and calmodulin are critical for 4ß1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants

VEGF therapy: risky business for established plaques?

What is WHIM syndrome?

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Clínical trials and olbservations

Prognostic significance of early vaso-occlusive complications in children with sickle cell anemia

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children\'s Oncology Group

Hematopoiesis

Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus–truncated CXCR4

Hemostasis, thrombosis, and vascular biology

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)

Polymerization of fibrin: direct observation and quantification of individual B:b knob-hole interactions

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Immunology

Phospholipase C, calcium, and calmodulin are critical for 4ß1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants

The actin cloud induced by LFA-1–mediated outside-in signals lowers the threshold for T-cell activation

The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+CD25– T cells

Into the blood

VEGF therapy: risky business for established plaques?

VWD data worth 10 000 words

What is WHIM syndrome?

PLENARY PAPERS

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFß dosage.

RED CELLS

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Transplantation

Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell–depleted reduced-intensity transplantation

Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines