Annals ofHematology

Volume: 8 - Number: 75 - June 15, 2008

Outstanding

The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas

Receptor activator of nuclear factor (NF)–B ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice

Scientific detectives solve ashen mutant problem

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Chemoquines, cytokines and interleuquinas

Shear flow–dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm

Clinical trials and observations

Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)

Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience

Gene Therapy

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

Hematopoiesis

The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor

The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis

Toll-like receptors and their ligands control mesenchymal stem cell functions

Hemostasis, thrombosis, and vascular biology

Receptor activator of nuclear factor (NF)–B ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice

The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation

The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies

The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules

Immunobiology

The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling

Inside blood

Scientific detectives solve ashen mutant problem

Neoplasia

ß common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)

The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas

Red Cells

Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes

Stem cells in hematology

SSEA-4 identifies mesenchymal stem cells from bone marrow

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Transplantation

The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia