Annals ofHematology

Volume: 10 - Number: 94 - January 14, 2010

Outstanding

Brief report mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

Blood group antigens reveal their maker

Complement dances with T cells

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Immunobiology

A novel polymorphism of the human CD40 receptor with enhanced function

Brief report Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome

Into the blood

Blood group antigens reveal their maker

Complement dances with T cells

Neoplasia

Absence of SKP2 expression attenuates BCR-ABL–induced myeloproliferative disease

Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny

Biologic and genetic characterization of the novel amyloidogenic lambda light chain–secreting human cell lines, ALMC-1 and ALMC-2

Brief report DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

Brief report Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl

Brief report mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

Brief report Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia

Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia

Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth

RED CELLS

Brief report Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

Transfusional medicine

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population

Transplantation

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies

Brief report A single nucleotide polymorphism at chromosome 2q21.3 (LCT –13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation

Brief report Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia

Brief report Expansion of donor-derived hematopoietic stem cells with PIGA mutation associated with late graft failure after allogeneic stem cell transplantation