Annals ofHematology

Volume: 10 - Number: 101 - August 15, 2010

Outstanding

Antimyeloperoxidase antibodies rapidly induce 4-integrin–dependent glomerular neutrophil adhesion

IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and T cells in vivo

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

Clinical trials and observations

IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection

Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy

Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up

Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia

Brief report Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions

Hematopoyesis and stem cells

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

Immunobiology

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and T cells in vivo

Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence

Brief report Type I natural killer T cells suppress tumors caused by p53 loss in mice

Limphoid neoplasia

Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study

T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model

Myeloid neoplasia

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT2

Phagocytes, granulocitos, and myelopoyesis

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

Platelets and throbopoyesis

Negative regulation of activated 2 integrins during thrombopoiesis

Red cells, iron, and erytropoiesis

Short-chain fatty acid–mediated effects on erythropoiesis in primary definitive erythroid cells

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

Thrombosis and hemostasis

Brief report Rescue of coagulation factor VII function by the U1+5A snRNA

Transplantation

Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients

Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation

Vascular Biology

Antimyeloperoxidase antibodies rapidly induce 4-integrin–dependent glomerular neutrophil adhesion