Annals ofHIV - Aids

Volume: 4 - Number: 30 - June 15, 2005

Outstanding

Ritonavir exhibits anti-atherogenic properties on vascular smooth muscle cells.

Reduced bone density in HIV-infected women.

Drug switching and virologic-based endpoints in trials of antiretroviral drugs for HIV infection.

Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis.

Basic Sciences

Rate of decline of absolute number and percentage of CD4 T lymphocytes among HIV-1-infected adults in Dar es Salaam, Tanzania.

Functionally active HLA-G polymorphisms are associated with the risk of heterosexual HIV-1 infection in African women.

Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: restoration by antiretroviral therapy.

Differences in HIV-2 plasma viral load and immune activation in HIV-1 and HIV-2 dually infected persons and those infected with HIV-2 only in Abidjan, Cote D'Ivoire.

Ritonavir exhibits anti-atherogenic properties on vascular smooth muscle cells.

Early correction of cell cycle perturbations predicts the immunological response to therapy in HIV-infected patients

Tc1 effector diversity shows dissociated expression of granzyme B and interferon-[gamma] in HIV infection

Clinical science

Short- and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia

Reduced bone density in HIV-infected women.

Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients.

Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load.

Evidence of genotypic resistance diversity of archived and circulating viral strains in blood and semen of pre-treated HIV-infected men.

Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells: a controlled, prospective trial.

HIV-2 protease sequences of subtypes A and B harbor multiple mutations associated with protease inhibitor resistance in HIV-1.

Saquinavir drug exposure is not impaired by the boosted double protease inhibitor combination of lopinavir/ritonavir.

Correspondence

Detection of stavudine concentrations in plasma of HIV-infected patients taking zidovudine.

Editorial reviews

Drug switching and virologic-based endpoints in trials of antiretroviral drugs for HIV infection.

Epidemiology & social

Gender and race do not alter early-life determinants of clinical disease progression in HIV-1 vertically infected children.

Frequent detection of acute primary HIV infection in men in Malawi.

The impact of HIV on mortality rates in the complete UK haemophilia population. UK Haemophilia Centre Doctors' Organisation

HIV prevalence in pregnant women in an ethnically diverse population in the UK: 1998-2002.

Highly active antiretroviral therapy and the incidence of HIV-1-associated nephropathy: a 12-year cohort study.

HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa.

Epidemiology of HIV-associated cryptococcosis in France (1985-2001): comparison of the pre- and post-HAART eras.

Research letters

HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment.

Pharmacokinetics of indinavir/ritonavir (800/100 mg twice a day) combined with efavirenz in HIV-infected patients.

Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis.

Serological pattern 'anti-hepatitis B core alone' in HIV or hepatitis C virus-infected patients is not fully explained by hepatitis B surface antigen mutants.