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- INFECTOLOGY: -Association between plasma levels of eotaxin (CCL-11) and treatment response to interferon- and ribavirin in HIV/HCV co-infected patients
Objectives: To analyse the association between plasma chemokine levels at baseline and virological response to interferon- (IFN-) + ribavirin in human immunodeficiency virus (HIV)/hepatitis C virus ...
- INFECTOLOGY: -The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis
Objectives: Increased bone marrow iron levels in patients with haematological malignancies is an independent risk factor for developing invasive pulmonary aspergillosis (IPA), suggesting an ...
- TUBERCULOSIS DRUG RESISTANCE: -INFECTOLOGY: -Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal
Objectives: Extensively drug-resistant (XDR) tuberculosis (TB) threatens the global control of TB worldwide. Lisbon has a high XDR-TB rate [50% of the multidrug-resistant tuberculosis (MDR-TB)], ...
- VIRAL RESISTANCE IN HEPATITIS C: -Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
Promising results have been observed with an investigational drug class for hepatitis C (HCV), the specifically targeted antiviral therapies for hepatitis C (STAT-Cs), when combined with ...
- HIV INFECTION & INFECTOLOGY & CORONARY HEART DISEASE: -Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti‐HIV
Background. The risk of myocardial infarction (MI) in patients with human immunodeficiency virus (HIV) infection has been assessed in 13 anti‐HIV drugs in the Data Collection on Adverse Events ...
- INFECTOLOGY: -A Postinfluenza model of staphylococcus aureus pneumonia
Background.Postinfluenza Staphylococcus aureus pneumonias are increasingly recognized as a major form of life‐threatening infections. Methods. A mouse model of postinfluenza S. aureus pneumonia ...
- VACCINATION & INFECTOLOGY: -Safety and antibody response, including antibody persistence for 5 years, after primary vaccination or revaccination with pneumococcal polysaccharide vaccine in middle‐aged and older adults
Background. This study assessed antibody levels for 5 years after primary vaccination or revaccination with 23‐valent pneumococcal polysaccharide vaccine (PN23). Methods. Subjects were enrolled ...
- FULLTEXT: -VACCINES: -INFECTOLOGY: -Mask use, hand hygiene, and seasonal influenza‐like illness among young adults: a randomized intervention trial
Background. During the influenza A(H1N1) pandemic, antiviral prescribing was limited, vaccines were not available early, and the effectiveness of nonpharmaceutical interventions (NPIs) was uncertain. ...
- FULLTEXT: PATHOGENESIS OF GENITAL HERPESVIRUS: -INFECTOLOGY & WOMEN HEALTH: -An evolving understanding of genital herpes pathogenesis: is it time for our approach to therapy to change as well?
In this issue of the Journal, Tata and coworkers present data from a small, intensively studied group of women with genital herpes due to herpes simplex virus (HSV) type 2, demonstrating that during ...
- FULLTEXT:- INFECTOLOGY: -Unmasking the confusion of respiratory protection to prevent influenza‐like illness in crowded community settings
The 2009 novel influenza A(H1N1) (hereafter “nH1N1”) pandemic has sparked renewed interest in, and controversy regarding, the use of respiratory protection to reduce influenza transmission. Use of ...
- INFECTOLOGY: -LYME DISEASE TREATMENT: -Antibiotic treatment duration and long‐term outcomes of patients with early lyme disease from a lyme disease–hyperendemic area
Background. The length of antibiotic therapy and long‐term outcomes in patients with early Lyme disease are incompletely described. We report the long‐term clinical outcomes of patients ...
- INFECTOLOGY: -HEPATOLOGY: -Incidence and risk factors for chronic elevation of alanine aminotransferase levels in hiv‐infected persons without hepatitis B or C virus co‐infection
Background. Chronic liver disease in human immunodeficiency virus (HIV)–infected patients is mostly caused by hepatitis virus co‐infection. Other reasons for chronic alanine aminotransferase ...
- INFECTOLOGY: HUMAN IMMUNE RESPONSE TO STRETOCOCCAL: -The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications
Background. Determination of an immune response to group A Streptococcus (GAS) antigens, frequently anti–streptolysin O and anti–DNase B, is crucial for documentation of bona fide GAS infection. ...
- INFECTOLOGY IN CRITICAL CARE: -Inadequate statistical power of published comparative cohort studies on ventilator‐associated pneumonia to detect mortality differences
Background. Comparative cohort studies are often conducted to identify novel therapeutic strategies or prognostic factors for ventilator‐associated pneumonia (VAP). We aimed to evaluate the ...
- INFECTOLOGY & VACCINATION: -Mandatory influenza vaccination of health care workers: translating policy to practice
Background. Influenza vaccination of health care workers has been recommended since 1984. Multiple strategies to enhance vaccination rates have been suggested, but national rates have remained low. ...
