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- PLASMODIUM RESISTANT: - INFECTOLOGY AND PARASITOLOGY:High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrim
Objectives: The frequency of dhfr and dhps point mutations was assessed in Plasmodium falciparum isolates from pregnant women in Libreville. Methods: PCR–restriction fragment length polymorphism of ...
- INFECTOLOGY: -Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells
Objectives: Our aim was to analyse the evolution of HIV-1 2-long terminal repeat (2-LTR) circular DNA in vitro and ex vivo in the presence of raltegravir. Patients and methods: Twenty-five patients ...
- PHARMACOLOGY & INFECTOLOGY: -Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir
Objectives: To understand the dynamic viral evolution observed during failure on raltegravir-containing regimens, we studied the genotypic and phenotypic patterns of resistance to raltegravir and ...
- ANTIVIRAL RESISTANCE: -HIV INFECTION AND MARAVIROX: -Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5
Objectives: Identification of CCR5 as an antiretroviral target led to the development of several CCR5 antagonists in clinical trials and the approval of maraviroc. Evaluating the mechanism of drug ...
- FULLTEXT: - PARASITOLOGY & MALARIA & INFECTOLOGY: -In vitro selection of Plasmodium falciparum drug-resistant parasite lines
Abstract The in vitro selection of antimicrobial resistance in important pathogens can provide critical information on the genetic basis of drug resistance, and such information can be ...
- FULLTEXT: -INFECTOLOGY: Pre‐existing minority drug‐resistant HIV‐1 variants, adherence, and risk of antiretroviral treatment failure
Background. The clinical relevance of detecting minority drug‐resistant human immunodeficiency virus type 1 (HIV‐1) variants is uncertain. Methods. To determine the effect of ...
- INFECTOLOGY: -Susceptibility of Human Th17 cells to human immunodeficiency virus and their perturbation during infection
Background. Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) ...
- INFECTOLOGY: -HIV/AIDS: -Activity of elvitegravir, a once‐daily integrase inhibitor, against resistant HIV type 1: results of a phase 2, randomized, controlled, dose‐ranging clinical trial
Background. This phase 2, randomized, active‐controlled, 48‐week study assessed the noninferiority of the human immunodeficiency virus (HIV) integrase inhibitor elvitegravir to comparator ...
- INFECTOLOGY: - HIV/AIDS: -Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus
Background. Because activation of T cells is associated with human immunodeficiency virus (HIV) pathogenesis, CD4 and CD8 activation levels in patients coinfected with HIV and hepatitis C virus (HCV) ...
- INFECTOLOGY: -Maraviroc versus efavirenz, both in combination with zidovudine‐lamivudine, for the treatment of antiretroviral‐naive subjects with ccr5‐tropic HIV ‐1 infection
Background. The MERIT (Maraviroc versus Efavirenz in Treatment‐Naive Patients) study compared maraviroc and efavirenz, both with zidovudine‐lamivudine, in antiretroviral‐naive ...
- FULLTEXT: -INFECTOLOGY: -Safety of 3 different reintroduction regimens of antituberculosis drugs after development of antituberculosis treatment–induced hepatotoxicity
Background. Drug‐induced hepatotoxicity (DIH) is the most common adverse drug reaction leading to interruption of antituberculosis treatment. Worldwide, different reintroduction regimens have ...
- INFECTOLOGY: -Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid‐resistant staphylococcus aureus
Background. From April through June 2008, we identified 12 patients in the intensive care unit and 3 patients on other wards infected with methicillin‐resistant Staphylococcus aureus that was ...
- INFECTOLOGY: -EMPYEMA COMPLICATING PNEUMONIA IN CHILDREN WITH COMMUNITY ADQUIRED PNEUMONIA: - Increasing incidence of empyema complicating childhood community‐acquired pneumonia in the United States
Background. The incidence of childhood pneumonia decreased following introduction of 7‐valent pneumococcal conjugate vaccine (PCV7) in the United States. Recent regional reports suggest an ...
- INFECTOLOGY & NEUROLOGY: -Blastomycosis of the central nervous system: a multicenter review of diagnosis and treatment in the modern era
Background. Central nervous system (CNS) involvement with Blastomyces dermatitidis is an uncommon and potentially fatal complication of blastomycosis. Methods. We retrospectively reviewed 22 patients ...
- INFECTION CONTROL: -Inactivating influenza viruses on surfaces using hydrogen peroxide or triethylene glycol at low vapor concentrations
Background Surfaces in congregate settings, such as vehicles used for mass transportation, can become contaminated with infectious microorganisms and facilitate disease transmission. We disinfected ...
