Annals ofClinical Investigation

Volume: 1 - Number: 1 - October 15, 2001

Outstanding

Articles

Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D

Urokinase-derived peptides regulate vascular smooth muscle contraction in vitro and in vivo

A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo

High-level expression of active HIV-1 integrase from a synthetic gene in human cells

A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-alfa and IL-6 secretion in the spleen

Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death

Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C

Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism

Natriuretic peptides: a new lipolytic pathway in human adipocytes

Mechanisms and implications of the age-associated decrease in DNA repair capacity

A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis

Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia

Placental isoprostane is significantly increased in preeclampsia

Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson’s disease

Viral mutation accelerated by nitric oxide production during infection in vivo

A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis

Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?

Subacute NO generation induced by Alzheimer’s ß-amyloid in the living brain: reversal by inhibition of the inducible NO synthase

Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets

Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cells is associated with an early loss of cellular redox balance

A role for tyrosine phosphorylation in the regulation and sensitization of adenylate cyclase by melatonin

Evaluation of alfa1-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense

Reviews and Trials

Lysosome-related organelles

Putative role of neuronal 5-lipoxygenase in an aging brain