Annals ofClinical Investigation

Volume: 2 - Number: 14 - November 1, 2002

Outstanding

TGF-ß antagonists: Why suppress a tumor suppressor?

Tissue plasminogen activator and seizures: a clot-buster’s secret life

Acinar-to-ductal metaplasia in pancreatic cancer development

Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine

Articles

Deficient natural killer cell cytotoxicity in patients with IKK-/NEMO mutations

p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling

Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction

Induction of CD4+ T cell–dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

Blockade of TGF-ß inhibits mammary tumor cell viability, migration, and metastases

Commentaries

Cellular sensors of feast and famine

TGF-ß antagonists: Why suppress a tumor suppressor?

Tissue plasminogen activator and seizures: a clot-buster’s secret life

Optimizing hematopoietic recovery following bone marrow transplantation

Acinar-to-ductal metaplasia in pancreatic cancer development

The thyroid axis just got more complicated

Focus

Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine

Perspectives

Series Introduction: New directions in vaccine research

Exploiting dendritic cells to improve vaccine efficacy