Annals ofClinical Investigation

Volume: 3 - Number: 17 - February 15, 2003

Outstanding

T cell homeostatic proliferation elicits effective antitumor autoimmunity

The TSH receptor reveals itself

Regulation of renin expression and blood pressure by vitamin D4

Increased C5a receptor expression in sepsis

Articles

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

Autoimmunity

Multiantigen/multiepitope–directed immune-specific suppression of "complex autoimmune encephalomyelitis" by a novel protein product of a synthetic gene

T cell homeostatic proliferation elicits effective antitumor autoimmunity

Cardiac and Vascular Biology

Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride

Cellular Biology

G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells

Circulation

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

Development Biology

Hepatocyte-specific inhibition of NF-B leads to apoptosis after TNF treatment, but not after partial hepatectomy

The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis

Endocrinology

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

The TSH receptor reveals itself

Regulation of renin expression and blood pressure by vitamin D4

Genetic

Signaling through estrogen receptors modulates telomerase activity in human prostate cancer

Immunology

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes

Making room for T cells

Development of an improved vaccine for anthrax

Inflammation

Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

Metabolism

Human cholesterol 7-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

Nephrology

Essential role of Gas6 for glomerular injury in nephrotoxic nephritis

Pneumonology

Viral induction of a chronic asthma phenotype and genetic segregation from the acute response

Sepsis and Infection

Increased C5a receptor expression in sepsis

Vascular Medicine

Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels

The surprising role of vascular KATP channels in vasospastic angina

Virology

Herpes simplex viruses: is a vaccine tenable?