Annals ofClinical Investigation

Volume: 5 - Number: 37 - January 15, 2005

Outstanding

Turnover of lymphocytes and conceptual paradigms in HIV infection

HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy

Tracking autoimmune T cells in diabetes

Women’s health and clinical trials

Articles

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

JunD protects against chronic kidney disease by regulating paracrine mitogens

Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas

Cardiac hypertrophy and histone deacetylase–dependent transcriptional repression mediated by the atypical homeodomain protein Hop

CD69 downregulates autoimmune reactivity through active transforming growth factor-ß production in collagen-induced arthritis

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow–derived cells

D-ß-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

A crucial role for thiol antioxidants in estrogen-deficiency bone loss

Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice

PKC in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Biosynthesis of 15-deoxy-12,14-PGJ2 and the ligation of PPAR

Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection

Commentary

Turnover of lymphocytes and conceptual paradigms in HIV infection

HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy

Tracking autoimmune T cells in diabetes

15-deoxy-12,14-PGJ2: endogenous PPAR ligand or minor eicosanoid degradation product?

Editorial

The JCI’s commitment to excellence — and free access

News

The growing pains of biodefense

Science and society

New ideas in asthma and allergy research: creating a multidisciplinary graduate school

Women’s health and clinical trials

Science in Medicine

Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias