Annals ofClinical Investigation

Volume: 5 - Number: 39 - March 15, 2005

Outstanding

The yin and yang of rheumatoid arthritis

What brings pericytes to tumor vessels?

Receptor "cross talk" in innate immunity

A novel role for uroguanylin in the regulation of sodium balance

Articles

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

A population of c-Kitlow(CD45/TER119)– hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids

Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum

Inhibition of NF-B activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction

FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice

Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase

Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load

Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS

Commentaries

What brings pericytes to tumor vessels?

Receptor "cross talk" in innate immunity

A novel role for uroguanylin in the regulation of sodium balance

News

The yin and yang of rheumatoid arthritis

Science and society

The WTO’s balancing act

Genetic counselors: translating genomic science into clinical practice

Spotlight

Neurogenesis and brain injury: managing a renewable resource for repair