Annals ofClinical Investigation

Volume: 5 - Number: 42 - July 15, 2005

Outstanding

Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions

Articles

Stat-3 is required for pulmonary homeostasis during hyperoxia

Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo

Cytotoxic T lymphocytes form an antigen-independent ring junction

Critical roles of TRAIL in hepatic cell death and hepatic inflammation

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient

Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

Nitrite in saliva increases gastric mucosal blood flow and mucus thickness

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR

Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

Bone marrow–derived progenitor cells in pulmonary fibrosis

Impaired Smad7-Smurf–mediated negative regulation of TGF-ß signaling in scleroderma fibroblasts

Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions

CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism

Commentaries

Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion

New viruses shake old paradigms

East meets West: an herbal tea finds a receptor

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

Perspective Series

Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

When cells get stressed: an integrative view of cellular senescence

Spotlight

VEGF: a critical player in neurodegeneration