Annals ofClinical Investigation

Volume: 5 - Number: 45 - October 15, 2005

Outstanding

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment

Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

Commentaries

Mining yeast in silico unearths a golden nugget for mitochondrial biology

Give me A5 for lipoprotein hydrolysis!

Shifting gears: liver SR-BI drives reverse cholesterol transport in macrophages

Editorial

Don’t be stupid about intelligent design

Investigational Article

Human 1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by 1ß1 integrin

Reversal of experimental pulmonary hypertension by PDGF inhibition

An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism

MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO)

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor

Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment

Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo

Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum

Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions

Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

Review

Pharmacological manipulation of cell death: clinical applications in sight?

The survival kinases Akt and Pim as potential pharmacological targets

Autophagy in cell death: an innocent convict?

Science and society

Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood

Science in Medicine

Kidney stone disease