Annals ofClinical Investigation

Volume: 6 - Number: 50 - March 15, 2006

Outstanding

Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?

Insulin’s effect on the liver: "Direct or indirect?" continues to be the question

C5a and Fc receptors: a mutual admiration society

Mucus in chronic airway diseases: sorting out the sticky details

Commentaries

SIDS: genetic and environmental influences may cause arrhythmia in this silent killer

Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?

Insulin’s effect on the liver: "Direct or indirect?" continues to be the question

C5a and Fc receptors: a mutual admiration society

Mucus in chronic airway diseases: sorting out the sticky details

Investigational Article

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8+ T cell-mediated, TNF-dependent immunopathology

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

Toll-like receptor 2 controls expansion and function of regulatory T cells

Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin

Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice

Insulin’s direct effects on the liver dominate the control of hepatic glucose production

c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs

Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

Science in Medicine

Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes