Annals ofClinical Investigation

Volume: 6 - Number: 51 - April 15, 2006

Outstanding

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction

GM-CSF action in the CNS decreases food intake and body weight

B cells: no longer bystanders in liver fibrosis

All neuropathies great and small

Articles

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-ß deposition in an Alzheimer disease mouse model

A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection

Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1ß–induced neovascularization and tumor growth

Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction

A cancer-specific transcriptional signature in human neoplasia

Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine

GM-CSF action in the CNS decreases food intake and body weight

Cardiac-specific overexpression of AT1 receptor mutant lacking Gq/Gi coupling causes hypertrophy and bradycardia in transgenic mice

Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-B decoy oligonucleotides

Attenuated liver fibrosis in the absence of B cells

BLyS and APRIL in rheumatoid arthritis

NKT cell–dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs

Articles briefing

Articles in brief

Commentaries

B cells: no longer bystanders in liver fibrosis

CD36 may determine our desire for dietary fats

All neuropathies great and small

When 7 transmembrane receptors are not G protein–coupled receptors

Variable phenotypic expression of mutations in genes of the immune system

New insights into nNOS regulation of vascular homeostasis