Annals ofClinical Investigation

Volume: 6 - Number: 57 - October 15, 2006

Outstanding

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

Ghrelin action in the brain controls adipocyte metabolism

Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

Investigational Article

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines

Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

Liver X receptors regulate adrenal cholesterol balance

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion

Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

In vivo antigen delivery by aSalmonella typhimurium type III secretion system for therapeutic cancer vaccines

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice

Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies

Ghrelin action in the brain controls adipocyte metabolism

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

Possible axonal regrowth in late recovery from the minimally conscious state

Suppression of canonical Wnt/ß-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

The IL-21 receptor augments Th2 effector function and alternative macrophage activation