Annals ofClinical Investigation

Volume: 6 - Number: 59 - December 15, 2006

Outstanding

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

Endocarditis and biofilm-associated pili of Enterococcus faecalis

Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling

Children are not little adults: just ask their hematopoietic stem cells

Commentaries

Children are not little adults: just ask their hematopoietic stem cells

Dysfunction of TGF-ß signaling in Alzheimer’s disease

Editorial

Can I quote you on that?

Investigational Article

Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone ß receptor inhibits mitotic progression

Absence of bacterially induced RELMß reduces injury in the dextran sodium sulfate model of colitis

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

CXCR2 ligands and G-CSF mediate PKC-induced intraepidermal inflammation

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation

Deficiency in neuronal TGF-ß signaling promotes neurodegeneration and Alzheimer’s pathology

Endocarditis and biofilm-associated pili of Enterococcus faecalis

Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling

Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice

Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

Note

A man who has made his Marks on science

Review

Deiodinases: implications of the local control of thyroid hormone action

Science and society

Drug discovery in jeopardy