Annals ofClinical Investigation

Volume: 7 - Number: 61 - February 15, 2007

Outstanding

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice

Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

TLR4 links innate immunity and fatty acid–induced insulin resistance

Commentaries

Role for IKK2 in muscle: waste not, want not

Shaping the sperm head: an ER enzyme leaves its mark

T cell activation alters intestinal structure and function

The paradoxical patent ductus arteriosus

To be or not to be B7

Investigational Article

Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice

Role of different pathways of the complement cascade in experimental bullous pemphigoid

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice

TLR4 links innate immunity and fatty acid–induced insulin resistance

TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents

Toll-like receptor 4 deficiency causes pulmonary emphysema

Transcription factor MITF regulates cardiac growth and hypertrophy

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection

VSIG4, a B7 family–related protein, is a negative regulator of T cell activation

Letters

Response to Windahl et al.

Response to Zhou et al.

Personal Perspective

The physician-scientist, the state, and the oath: thoughts for our times