Annals ofClinical Investigation

Volume: 7 - Number: 66 - July 15, 2007

Outstanding

Inhibition of TGF-ß with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Inhibition of p38 MAPK rescues cardiomyopathy induced by overexpressed ß2-adrenergic receptor, but not ß1-adrenergic receptor

Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance

Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation

Research article

A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome

Homeostatically proliferating CD4+ T cells are involved in the pathogenesis of an Omenn syndrome murine model

Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS–induced lung cancer

Inhibition of TGF-ß with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity

Inhibition of p38 MAPK rescues cardiomyopathy induced by overexpressed ß2-adrenergic receptor, but not ß1-adrenergic receptor

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca2+ release channel

Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy

Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation

Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus

CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage

Fanconi anemia pathway–deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated