Annals ofClinical Investigation

Volume: 7 - Number: 67 - August 15, 2007

Outstanding

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

Cardiac autophagy is a maladaptive response to hemodynamic stress

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell–associated antigens

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury

Commentaries

"AMPing up" our understanding of the hypothalamic control of energy balance

AHSP: a novel hemoglobin helper

Applying the discovery of the Philadelphia chromosome

Chain-reaction Ca2+ signaling in the heart

Investigational Article

A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

An erythroid chaperone that facilitates folding of -globin subunits for hemoglobin synthesis

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia

Cardiac autophagy is a maladaptive response to hemodynamic stress

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell–associated antigens

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease

Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator–dependent system in gut

Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury

Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

FKBP52 deficiency–conferred uterine progesterone resistance is genetic background and pregnancy stage specific

Review series

Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications

Discovery of the Philadelphia chromosome: a personal perspective

ErbB receptors: from oncogenes to targeted cancer therapies