Annals ofClinical Investigation

Volume: 7 - Number: 69 - October 15, 2007

Outstanding

Muscle-specific knockout of PKC- impairs glucose transport and induces metabolic and diabetic syndromes

Neutrophil-mediated innate immune resistance to mycobacteria

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Prime suspect: the TCF7L2 gene and type 2 diabetes risk

Commentaries

New TB vaccines: is there a requirement for CD8+ T cells?

p53, chemokines, and squamous cell carcinoma

Prime suspect: the TCF7L2 gene and type 2 diabetes risk

Proteinuria: is it all in the foot?

Regulation of erythrocyte lifespan: do reactive oxygen species set the clock?

Retroviral integration and human gene therapy

Investigational Article

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

Muscle-specific knockout of PKC- impairs glucose transport and induces metabolic and diabetic syndromes

Neutrophil-mediated innate immune resistance to mycobacteria

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Priming and effector dependence on insulin B:9–23 peptide in NOD islet autoimmunity

Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1–mediated tumor apoptotic switch

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus

SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling

Src promotes estrogen-dependent estrogen receptor proteolysis in human breast cancer

The antithrombotic potential of selective blockade of talin-dependent integrin IIbß3 (platelet GPIIb–IIIa) activation

Review series

Stem cells in prostate cancer initiation and progression