Annals ofClinical Investigation

Volume: 8 - Number: 72 - January 15, 2008

Outstanding

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLC2 signaling axis in mice

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice

Macrophages feel their age in macular degeneration

Commentaries

Macrophages feel their age in macular degeneration

OX40 signaling directly triggers the antitumor effects of NKT cells

When it comes to opiates, just say NO

Investigational Article

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLC2 signaling axis in mice

NK cell survival mediated through the regulatory synapse with human DCs requires IL-15R

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice

Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor–1

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice

Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

Survival prediction of stage I lung adenocarcinomas by expression of 10 genes

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

The central melanocortin system directly controls peripheral lipid metabolism

The function of heme-regulated eIF2 kinase in murine iron homeostasis and macrophage maturation

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice

TNF- induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells

Valsartan lowers brain ß-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

Science in Medicine

Understanding the benign nature of SIV infection in natural hosts

Technical's Advances

Portable flanking sequences modulate CTL epitope processing