Annals ofClinical Investigation

Volume: 11 - Number: 108 - January 15, 2011

Outstanding

Commentaries

The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?

Which species are in your feces?

Integral role of integrins in Th17 development

A tincture of hepcidin cures all: the potential for hepcidin therapeutics

Can TNF-? boost regulatory T cells?

Can we build it better? Using BAC genetics to engineer more effective cytomegalovirus vaccines

Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?

Learning about genomics and disease from the anucleate human red blood cell

In This Number

In This Issue

Investigational Article

Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity

Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis

Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans

News

Thrivin’ (not just survivin’) in Philadelphia

Science in Medicine

Advances and challenges in malaria vaccine development