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- LIPIDS: Preparation of pure lipid hydroperoxides
Increasing evidence of lipid peroxidation in food deterioration and pathophysiology of diseases have revealed the need for a pure lipid hydroperoxide (LOOH) reference as an authentic standard for ...
- LIPIDS: -A new mouse mutant for the LDL receptor identified using ENU mutagenesis
In an effort to discover new mouse models of cardiovascular disease using ENU mutagenesis followed by high-throughput phenotyping, we have identified a new mouse mutation, C699Y, in the LDL receptor ...
- LIPIDS: -Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo
Eight proteins potentially involved in cholesterol efflux (ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), SR-B1, caveolin-1, cholesteryl ester transfer protein (CETP) and apolipoprotein ...
- DIET & LIPIDS: Low-carb and Mediterranean diets beat low-fat for weight-loss, lipid changes at two years
Both a low-carbohydrate diet or a Mediterranean-style diet may be "effective alternatives" to a low-fat diet, with more favorable effects on lipids and/or glycemic control, new research suggests1. ...
- LIPIDS: -Niacin/laropiprant combination approved in European Union, Iceland, and Norway
The novel combination of niacin and laropiprant (Tredaptive, Merck) is now approved in the European Union, as well as Iceland and Norway, and is available for use in patients with dyslipidemia and ...
- LIPIDS : -CD36 variants influence ability of fish oil to lower triglycerides
Prostaglandins Leukot Essent Fatty Acids 2008; 78: 327-335 Reduction in triglycerides in healthy middle-aged men as a result of fish oil supplementation is influenced by their CD36 genotype, report ...
- LIPIDS: -Red yeast rice and fish oil rival simvastatin for lipid-lowering ability
Mayo Clin Proc 2008; 83: 758-764 A combination of red yeast rice and fish oil supplementation as well as lifestyle changes lowers low-density lipoprotein (LDL) cholesterol by similar ...
- LIPIDS: -High blood EPA and DPA reduce nonfatal MI risk in women
Am J Clin Nutr 2008; 88: 216-223 Elevated blood plasma levels of eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) are associated with reduced risk for nonfatal myocardial infarction (MI) ...
- LIPIDS: -CASHMERE Study: -No IMT effect with atorvastatin over 12 months
A small but intriguing clinical trial has shown that atorvastatin (Lipitor, Pfizer) was no more effective than placebo in slowing the progression of atherosclerosis1. Over the course of the 12-month ...
- LIPIDS & OBESITY:- Obesity epidemic in children fuels need for new recommendations in lipid screening and cardiovascular health
The American Academy of Pediatrics has issued a new clinical report on lipid screening and cardiovascular health in children1, a report that has taken on new urgency given the epidemic of childhood ...
- CARDIOVASCULAR RISK: -HRT: -LIPIDS & LIPOPROTEIN(a) CV RISK: -Estrogen hampers Lp(a) use for risk prediction
The utility of Lp(a) in predicting the future risk of heart disease is markedly attenuated among women taking hormone therapy, a new study suggests1. The study, published online July 1, 2008 in the ...
- WOMEN HEALTH: - HRT & G & O: LIPIDS: - Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events
Objectives: This study assesses whether the relationship of lipoprotein(a) [Lp(a)] with cardiovascular risk may be modified by concurrent hormone replacement therapy (HT). Background: Prior ...
- LIPIDS: - Hepatic over-expression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport
Neutral Cholesteryl ester hydrolase (CEH) mediated hydrolysis of cellular cholesteryl esters (CE) is required not only to generate free cholesterol for efflux from macrophages but also to release FC ...
- LIPIDS: - Compartmentalization of stearoyl-CoA desaturase enzyme-1 activity in HepG2 cells
Stearoyl-CoA desaturase 1 (SCD1) catalyzes conversion of stearate (18:0) to oleate (18:1n-9), and palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty ...
- LIPIDS & CARDIOVASCULAR MEDICINE: -Leukocyte-derived hepatic lipase deficiency in female LDL receptor-deficient mice expressing human CETP decreases plasma HDL and increases en face aortic atherosclerosis
In addition to hepatic expression, cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are expressed by human macrophages. The combined actions of these proteins have profound effects ...
