In this issue of the Journal, Pedchenko et al.1 increase our understanding of the pathogenesis of two forms of antibody-mediated glomerulonephritis. One, Goodpasture's disease, is an ...

Background In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and ...

Decrements in kidney function occur in more than two thirds of hospitalized patients with critical illness,1 and severe acute kidney injury complicates the care of more than 5% of patients who ...

Background The optimal intensity of continuous renal-replacement therapy remains unclear. We conducted a multicenter, randomized trial to compare the effect of this therapy, delivered at two ...

To the Editor: We report a negative effect of initiation of dialysis on independent living by patients 80 years of age or older. Using a single-center, retrolective cohort study design (involving ...

Background It is unclear whether functional status before dialysis is maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD). Methods Using a ...

To the Editor: Bosch and colleagues (July 2 issue)1 observe that although conventional hemodialysis filters do not remove myoglobin (molecular weight, 17.8 kD), hemodiafiltration with super-high-flux ...