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- MULTIPLE SCLEROSIS: -Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis
Stability of the myelin-axon unit is achieved, at least in part, by specialized paranodal junctions comprised of the neuronal heterocomplex of contactin and contactin-associated protein and the ...
- NEUROLOGY: -Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4. It has recently been ...
- FULLTEXT: -NEUROLOGY: -Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling
Summary The primary biological function of the endogenous cellular prion protein has remained unclear. We investigated its biological function in the generation of cellular immune responses using ...
- FULLTEXT: -MULTIPLE SCLEROSIS: -Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve
Summary The cognitive reserve hypothesis helps to explain the incomplete relationship between brain disease and cognitive status in people with neurologic diseases, including Alzheimer's; ...
- NEUROLOGY: -Intraparenchymal hemorrhage in a patient with osteogenesis imperfecta and plasminogen activator inhibitor-1 deficiency
Background Osteogenesis imperfecta is associated with susceptibility to connective tissue damage, including intracranial but usually extra-axial hemorrhage. Plasminogen activator inhibitor-1 ...
- SCOLIOSIS SURGERY: -NEUROLOGY: -Scoliosis surgery in children with neuromuscular disease
Background Scoliosis is a frequent complication of pediatric neuromuscular disease (NMD). Scoliosis surgery in children with NMD is thought to carry greater morbidity and mortality. ...
- NEUROLOGY: -Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults
Background Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration. Objective ...
- AUTOIMMUNE NEUROLOGY: -Autoantibody-mediated dysfunction of sympathetic neurons in Guillain-Barré Syndrome
Objective To investigate a pathologic immune response to autonomic nerve fibers in Guillain-Barré syndrome (GBS). Design We compared the effects of purified IgG from patients with GBS, ...
- NEUROLOGY: -Blood–brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9
Background and Purpose Matrix metalloproteinases (MMP) may play a role in blood–brain barrier (BBB) disruption after ischemic stroke. We hypothesized that plasma concentrations of MMP-9 are ...
- HYPERTENSION: -Hypertension, executive dysfunction, and progression to dementia
Background Midlife hypertension has long been established as a risk factor for dementia, but the role of late-life hypertension remains unclear. Objective To investigate the role of ...
- CEREBROVASCULAR DISEASE: -Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis
Objective To assess the effect of more intensive medical therapy on the rate of transcranial Doppler (TCD) microemboli and cardiovascular events in patients with asymptomatic carotid stenosis ...
- WOMEN HEALTH: -CEREBROVASCULAR DISEASE: -Prospective study of endogenous circulating estradiol and risk of stroke in older women
Objective To test the hypothesis that circulating endogenous estradiol is associated with stroke risk in older postmenopausal women. Stroke incidence increases after menopause, when ...
- NEUROBIOLOGY: -Alzheimer disease–like phenotype associated with the c.154dela mutation in progranulin
Objective To characterize a kindred with a familial neurodegenerative disorder associated with a mutation in progranulin (PGRN), with emphasis on the unique clinical features in this kindred. ...
- NEUROPATHOLOGY & Brain -synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation
-Synuclein is a major component of Lewy bodies and glial cytoplasmic inclusions, pathological hallmarks of idiopathic Parkinson's disease and multiple system atrophy, and it is assumed to be ...
- CEREBROVASCULAR DISEASE: Altered control of postural sway following cerebral infarction
Objective: Balance impairment is common following cerebral infarction. However, the effects of lesion hemisphere on postural control are largely unknown. We examined dependence upon vision and ...
