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- OSTEOLOGY: -Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older
Abstract & Summary Clinical performance of osteoporosis risk assessment tools was studied in women aged 67 years and older. Weight was as accurate as two of the tools to detect ...
- OSTEOLOGY: -Routine versus targeted vertebral fracture assessment for the detection of vertebral fractures
Abstract & Summary Fracture risk is underestimated in women with unknown vertebral fractures. Using VFA, we compared two screening methods: targeted (6,388 women) and routine (2,176 ...
- VASCULAR MEDICINE & OSTEOLOGY: -Progression of vascular calcifications is associated with greater bone loss and increased bone fractures
Abstract & Summary: In this prospective study, we found a positive relationship between the prevalence of aortic calcifications and age. Aortic calcifications at baseline were ...
- OSTEOLOGY: -Trend of hip fracture incidence in Germany 1995–2004: a population-based study
Summary We analyzed hip fracture incidence trends in Germany 1995-2004, using national hospital discharge register. Crude incidences per 100,000 increased from 121.2 (95% CI 120.5-121.9) ...
- OSTEOLOGY: Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis
The understanding of cell interactions and genetic controls of bone cells has provided new approaches to drug development for osteoporosis. Current emphasis in the development of new anabolic ...
- OSTEOLOGY: -Effect of calcium supplementation on hip fractures
There have been numerous studies of the effects of calcium supplementation, with or without vitamin D, on fractures. Individually, they have not provided clarity regarding calcium’s anti-fracture ...
- OSTEOLOGY & OSTEOPOROSIS: -Routine versus targeted vertebral fracture assessment for the detection of vertebral fractures
Abstract Paget’s disease of bone (PDB) is a potentially crippling condition. Pain, fracture, spinal stenosis, nerve entrapment, vascular steal syndrome, secondary osteoarthritis, bone deformity, ...
- OSTEOLOGY & OSTEOPOROSIS & FRACTURES: -BRAZOS reports major osteoporosis risk factors in general population
Osteoporos Int 2008; Advance online publication Scientists behind the Brazilian Osteoporosis Study (BRAZOS) believe they have identified the key risk factors for osteoporosis in the general ...
- OSTEOLOGY : - Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts
The second messenger molecule cyclic adenosine monophosphate (cAMP) plays an important role in the hormonal regulation of bone metabolism. cAMP is inactivated by the cyclic nucleotide ...
- OSTEOLOGY: - Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-. Effects dependent on activation of NF-κB and MAP kinases
Pro-inflammatory mediators formed by the kallikrein–kinin system can stimulate bone resorption and synergistically potentiate bone resorption induced by IL-1 and TNF-. We have shown that the effect ...
- OSTEOLOGY: The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model
Apert syndrome is caused by mutations in fibroblast growth factor receptor 2 (Fgfr2) and is characterized by craniosynostosis and other skeletal abnormalities. The Apert syndrome Fgfr2+/S252W mouse ...
- OSTEOLOGY: - The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells
Both mechanical loading and nitric oxide (NO) have positive influences on bone mass. NO production is induced by mechanical strain via upregulation of eNOS mRNA and protein, the predominant NOS in ...
- OSTEOLOGY: - Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation
To elucidate the mechanism of the effect of bisphosphonates on bone metabolism, we investigated the effect of alendronate, a widely used bisphosphonate, on osteogenic and adipogenic differentiation ...
- OSTEOLOGY: - Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells
Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed ...
- OSTEOLOGY : - Oxygen tension regulates preosteocyte maturation and mineralization
Oxygen availability is a critical signal for proper development of many tissues, however there is limited knowledge of its role in the maturation of bone cells. To test the hypothesis that low pO2 ...
