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- METABOLIC SYNDROME: -Increased renin production in mice with deletion of peroxisome proliferator-activated receptor- in juxtaglomerular cells
We recently found that endogenous (free fatty acids) and pharmacological (thiazolidinediones) agonists of nuclear receptor Peroxisome proliferator-activated receptor (PPAR) stimulate renin ...
- METABOLIC SYNDROME & OBESITY: -CORONARY HEART DISEASE: -The effect of obesity on quality of life in patients with diabetes and coronary artery disease
Background Obesity increases the risk of type 2 diabetes and coronary artery disease (CAD). Because all 3 conditions may reduce quality of life, the extent to which obesity, diabetes, and CAD ...
- METABOLIC SYNDROME & SECOND GENERATION ANTI-PSYCHOTICS AGENTS : -Metabolic testing rates in 3 state medicaid programs after FDA warnings and ADA/APA recommendations for second-generation antipsychotic drugs
Context In 2003, the Food and Drug Administration (FDA) required a warning on diabetes risk for second-generation antipsychotic (SGA) drugs. The American Diabetes Association (ADA) and ...
- METABOLIC SYNDROME: -Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-α ligands in Zucker rats
Abstract N-oleoylethanolamine (OEA) and N-palmitoylethanolamine (PEA) are endogenous lipids that activate peroxisome proliferator–activated receptor-α with high and intermediate potency, and ...
- METABOLIC SYNDROME: -Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet
ABSTRACT This study was designed to examine the effects of a high-fat, high-sucrose (HFHS) diet on vascular and metabolic actions of insulin. Male rats were randomized to receive an HFHS or regular ...
- METABOLIC SYNDROME: -Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men
Background The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk of cardiovascular disease and ...
- BREAST -FEEDING, ADIPOSITY IN ADOLESCENT & METABOLIC SYNDROME: -Breast-feeding modulates the influence of the peroxisome proliferator–activated receptor-γ (PPARG2) pro12ala polymorphism on adiposity in adolescents
OBJECTIVE The peroxisome proliferator–activated receptor-γ2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The ...
- ADIPOSITY & VISCERAL FAT AREA & INSULIN RESISTANCE MARKERS IN COLORECTAL CANCER: -Visceral fat area and markers of insulin resistance in relation to colorectal neoplasia
OBJECTIVE Although abdominal obesity and related metabolic abnormalities are hypothesized to promote colorectal carcinogenesis, direct confirmation of this effect is required. Here, we examined the ...
- FULLTEXT: -METABOLIC SYNDROME & CORONARY HEART DISEASE: -Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?
Other Sections▼ Abstract Introduction Methods Results Discussion Conclusion Competing interests Authors' contributions References Abstract & Backgrounds Adiponectin is an adipose ...
- HIGHLIGHT: -FULLTEXT: -METABOLIC & VASCULAR MEDICINE: -Mclk1+/- mice are not resistant to the development of atherosclerosis
Other Sections▼ , Abstract , Introduction , Methods , Results , Discussion , Conclusion , Competing interests , Authors' contributions , Authors' Information , References Abstract ...
- HIFGLIGHT: -FULLTEXT: -DISLYPIDEMIA & METABOLIC SYNDROME: -Angiogenesis in the New Zealand obese mouse model fed with high fat diet
Obesity and its complications lead to vascular injury, atherosclerosis, diabetes and pathological angiogenesis. One of the models to study the obesity and its entanglements is the New Zealand Obese ...
- HIGHLIGHT: -FULLTEXT: -METABOLIC SYNDROME & OBESITY AND ADIPOSITY: -IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized doubl
Abstract & Background A recent in vitro study indicates that IGOB131, a novel seed extract of the traditional West African food plant Irvingia gabonensis, favorably impacts adipogenesis through ...
- METABOLIC SYNDROME: -CCL5 promotes macrophage recruitment and survival in human white adipose tissue
Objectives To examine the role of adipose-produced chemokine, chemokine ligand (CCL) 5, on the recruitment and survival of macrophages in human white adipose tissue (WAT). Methods and Results CCL5 ...
- HIGHLIGHT: -METABOLIC SYNDROME: -Thiazolidinediones reduce pathological neovascularization in ischemic retina via an adiponectin-dependent mechanism
Background The insulin-sensitizing agents referred to as thiazolidinediones (TZDs) possess antiatherogenic and anti-inflammatory actions that contribute to protection against diabetic macrovascular ...
- HIGHLIGHT: -METABOLIC & INFLAMMATORY DISORDER: - Loss of Stearoyl-CoA Desaturase-1 attenuates adipocyte inflammation: Effects of adipocyte-derived Oleate
Background and Purpose Adipose inflammation is crucial to the pathogenesis of metabolic disorders. This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory ...
